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Inappropriate use of too-high doses of testosterone especially through injections ; can ultimately lead to a shutdown of the body's natural production of testosterone, resulting in impotence. Inappropriate use of other anabolic steroids can also cause impotence. Neuropathy. A form of neuropathy called autonomic neuropathy causes a number of serious symptoms in some HIV + people, including impotence in some men and possibly sexual arousal disorder in some women as well as digestive dysfunction, bladder problems, and orthostatic hypotension ; . Because autonomic neuropathy is more common than is generally recognized, it may be contributing to sexual dysfunction in far more HIV + people than has been reported to date. Researchers have found that HIV-positive men with neuropathy whether asymptomatic or symptomatic ; have nerve conduction problems that may explain their impotence. Normally, nerve signals propagate in pulses along nerves at a certain rate. Researchers have found that this rate is diminished in the dorsal back ; nerve of the penis in HIV + people with neuropathy. In contrast, the penile brachial index that measures blood pressure appears to be unimpaired. This indicates that the problem lies in the nerves, not in the blood supply to the penis. [For more information, see Neuropathy.] Medications. Many different medications can cause sexual problems. Included on the list of drugs that may be problematic are protease inhibitors, as well as a very long list of other medications. In a recent study of 254 HIV-positive men, the rate of sexual problems erectile dysfunction and or loss of libido ; was shown to be increased during any protease inhibitor therapy, with the rate most elevated in those using ritonavir, followed by indinavir, nelfinavir, and saquinavir. There was no apparent association of sexual dysfunction with the use of NNRTIs non-nucleoside reverse transcriptase inhibitors ; or NRTIs nucleoside analogue reverse transcriptase inhibitors or nukes ; . There are many other drugs that are known to have possible sexual side effects. In a compilation by Consumer Reports On Health March 2002 ; , common drugs that may cause sexual dysfunction were listed as the following note that this list does not include sexual dysfunction that may be caused by interactions between drugs ; : Drugs that may cause decreased sexual desire: Q Anti-anxiety drugs: alprazolam Xanax ; and diazepam Valium ; Q Anticonvulsants: carbamazepine Tegretol ; , phenytoin Dilantin ; , and primidone Myidone, Mysoline ; Q Antidepressants: amitriptyline Elavil ; , amoxapine Asendin ; , clomipramine Anafranil ; , desipramine Norpramin ; , fluoxetine Prozac ; , imipramine Norfranil, Tofranil ; , phenelzine Nardil ; , sertraline Zoloft ; , venlafaxine Effexor ; Q Antihypertensives blood pressure meds ; : atenolol Tenormin ; , chlorthalidone Hygroton, Thalitone ; , clonidine Catapres ; , hydrochlorothiazide Esidrix, HydroDIURIL ; , labetalol Normodyne, Trandate ; , methyldopa Aldomet ; , metoprolol Lopressor ; , propranolol Inderal ; , spironolactone Aldactone ; Q Enlarged-prostate drug: finasteride Proscar ; Q Hair loss male pattern baldness ; drug: finasteride Propecia ; Q Heartburn drugs: cimetidine Tagamet, Tagamet HB ; , famotidine Pepcid, Pepcid AC ; , nizatidine Axid, Axid AR ; , ranitidine Zantac, Zantac 75 ; Q Heart failure drug: amiodarone Cordarone ; Drugs that may cause erectile dysfunction or vaginal dryness: Q Anticonvulsants: carbamazepine Tegretol ; , phenytoin Dilantin ; , and primidone Myidone, Mysoline ; Q Antidepressants: amitriptyline Elavil ; , amoxapine Asendin ; , clomipramine Anafranil ; , desipramine Norpramin ; , fluoxetine Prozac ; , imipramine Norfranil, Tofranil ; , paroxetine Paxil ; , phenelzine Nardil ; , sertraline Zoloft ; , venlafaxine Effexor ; Q Antihypertensives blood pressure meds ; : atenolol Tenormin ; , chlorthalidone Hygroton, Thalitone ; , clonidine Catapres ; , hydrochlorothiazide Esidrix, HydroDIURIL ; , labetalol Normodyne, Trandate ; , methyldopa Aldomet ; , metoprolol Lopressor ; , propranolol Inderal ; , spironolactone Aldactone ; Q Enlarged-prostate drug: finasteride Proscar ; Q Hair loss male pattern baldness ; drug: finasteride Propecia ; Q Heartburn drugs: cimetidine Tagamet, Tagamet HB ; , famotidine Pepcid, Pepcid AC ; , nizatidine Axid, Axid AR ; , ranitidine Zantac, Zantac 75 ; Q Heart failure drug: amiodarone Cordarone ; Q Muscle relaxant: baclofen Lioresal!
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Abstract--Hyperplasia of pulmonary artery smooth muscle cells PA-SMCs ; is a hallmark pathological feature of pulmonary hypertension PH ; . Serotonin 5-HT ; is involved in the hyperplasia through its interactions with specific receptors and internalization by a specific plasma membrane transporter. We investigated the expression and role of the 5-HT transporter 5-HTT ; and 5-HT1B, 5-HT2A, and 5-HT2B receptors in lungs and isolated PA-SMCs from patients with primary PH n 14 ; , pulmonary veno-occlusive disease n 4 ; , or secondary PH SPH, n 8 ; and nonpulmonary hypertensive control subjects. Whereas strong immunostaining for the three receptor types and 5-HTT was seen in remodeled pulmonary vessels from patients in all PH categories, only 5-HTT expression was increased in lungs and cultured PA-SMCs from patients versus controls. The increased growth response of PA-SMCs from patients with primary PH, pulmonary veno-occlusive disease, or SPH to 5-HT or serum was entirely attributable to 5-HTT overexpression, because 5-HTT inhibitors but not 5-HT receptor antagonists abolished 5-HT mitogenic activity and reduced the serum-induced growth response to similar levels in patients as in controls. The L-allelic variant of the 5-HTT gene promoter, which is associated with 5-HTT overexpression, was present homozygously in 14 of 56% ; lung transplantation patients with SPH but in only 27% of controls. Polymorphism of the 5-HTT gene promoter was only partly responsible for the increased 5-HTT expression in PH, because PA-SMCs from patients exhibited higher 5-HTT levels than same-genotype cells from controls and no additional promoter sequence alterations were found. We conclude that 5-HTT overexpression is a common pathogenic mechanism in various forms of PH. Circ Res. 2004; 94: 12631270. ; Key Words: human pulmonary hypertension serotonin transporter pulmonary artery smooth muscle cells serotonin receptors. Type 1 This is the grade of diabetes where the pancreas does not produce any insulin at all so it is necessary for the insulin to be replaced in the body by other forms which can include injection. Type 2 This is a grade of diabetes where the individual only produces limited amounts of insulin so adaptations to the diet, or medication, is needed for control of the condition. UKPDS research trial United Kingdom Prospective Diabetes Study. A 20 year clinical research study of Type 2 diabetes, which showed that complications can be significantly reduced by appropriate treatment. September 1999. Unit A measurement used for alcohol or drugs medication, e.g. insulin and oretic, for example, tramadol. 2004-06-06 2004-05-10 2004-04-20 ADVR PRESENTED RESULTS OF ITS AVR118 PHASE 1 2 CLINICAL PROGRAM AT ASCO ADVR RECEIVES SECOND $3 MILLION INSTALLMENT OF FUNDING ADVANCED VIRAL RESEARCH CORP. ANNOUNCES THE RESIGNATION OF ITS CHIEF FINANCIAL OFFICER ADVR APPOINTS DR. CAROL EPSTEIN AS ACTING MEDICAL DIRECTOR.
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Activities, though he never complained. Last March, Zachary was hospitalized with sepsis and it became apparent to everyone that he would not be returning to school. His health continues to decline, and Zachary has been hospitalized many more times. In May it was decided that Zachary's body needed more help. He was anemic, diagnosed with Failure to Thrive and a zinc deficiency. His body had no reserve and he was losing muscle mass. A g-tube was placed to give him nutrition, but his immune system continued to fail. He could not return to school this year; instead he is Hospital Homebound. Zachary has speech, motor, and feeding problems for which he is receiving therapy to help overcome. No one knows what the future will hold for Zachary, but whatever it does, this little guy will face it with a smile and eulexin.

Reuters LONDON. Using a mobile phone does not increase the risk of developing glioma, the most common type of brain tumor, according to team of UK researchers. After a four-year survey, scientists at the Institute of Cancer Research in London and the universities of Leeds, Nottingham and Manchester found no link between regular, long-term use of mobile phones and glioma. "Overall, we found no raised risk of glioma associated with regular mobile phone use and no association with time since first use, lifetime years of use, cumulative hours of use, or number of calls, " said lead researcher Professor Patricia McKinney of the University of Leeds, in a report published in the British Medical Journal. The survey is the biggest of its kind to date. The researchers questioned 966 people with glioma brain tumors and 1, 716 healthy volunteers about how long they had used mobile phones, the make and model, how many calls they made and how long the calls lasted. Over the past two decades, the use of mobile phones has risen rapidly worldwide, but there has been no hard evidence to substantiate fears that the technology causes health problems ranging from headaches to brain tumors. Earlier mobile phones used analogue signals which emitted higher power signals than the later digital models. If there were health dangers from mobiles phones, they would be more likely to result from the earlier models, but the researchers found no evidence of it. The researchers conclude that there is a lack of convincing and consistent evidence that exposure to radio frequency fields has any effect on the risk of cancer. "Overall, our findings are consistent with this and with most studies on mobile phone use, " McKinney said. But most people taking the medicine for a long time will gain some weight and flutamide. Many interesting topics were in focus at the Annual Scientific Sessions of the American Diabetes Association ADA ; in San Francisco in June. Visitors joined the crowds at numerous symposia, multiple poster sessions, and the commercial exhibition. What follows is an overview of some notable issues discussed at this year's ADA, for example, pharmacist. ACOG Committee on Practice Bulletins-Gynecology. ACOG Practice Bulletin. The use of hormonal contraception in women with coexisting medical conditions. Int J Gynaecol Obstet 2001; 75: 93106. Marchbanks PA, McDonald JA, Wilson HG, et al. Oral contraceptives and the risk of breast cancer. N Engl J Med 2002; 346: 202532 and raloxifene.

Good quality food can help, plenty of fruit and fresh vegetables, broccoli, cauliflower, carrots and beans, stay away from what is called junk food, the immune system is what controls all of your health, it is the system that you were given when you were born and medicine has not developed anything to compare with the way it performs, for example, esidrix. Interfacility Guidelines June 2006 Definitions "Ambulance" has the meaning specified in s. 146.50 1 ; a ; , Stats., namely, an emergency vehicle, including any motor vehicle, boat or aircraft, whether privately or publicly owned, which is designed, constructed or equipped to transport sick, disabled or injured individuals. "Ambulance service" has the meaning specified in s.146.55 1 ; a ; , Stats., namely, the business of transporting sick, disabled or injured individuals by ambulance to or from facilities or institutions providing health services. "Ambulance service provider, " "ambulance provider" or "provider" has the meaning specified in s. 146.50 1 ; c ; , Stats., namely, a person engaged in the business of transporting sick, disabled or injured individuals by ambulance to or from facilities or institutions providing health services. "Basic life support" or "BLS" means emergency medical care that is rendered to a sick, disabled or injured individual, based on signs, symptoms or complaints, prior to the individual's hospitalization or while transporting the individual between health care facilities and that is limited to use of the knowledge, skills and techniques received from training under s. 146.50, Stats., and ch. HFS 110 as a condition for being issued an EMTbasic license. "Critical care and specialty care transport" means use of licensed health care personnel RN, NP, MD, DO, EMT-P, PA, RRT, etc. ; with hospital-defined and approved critical care skills and a scope of practice that is more comprehensive than that of an ALS ambulance service provider thereby allowing for the highest level of care available for emergent and or specialty e.g. obstetric, neonatal, pediatric, extracorporeal technology, etc. ; interfacility transport of patients with a high degree of clinical acuity and potential for deterioration. "Advanced life support" or "ALS" means use, by appropriately trained and licensed personnel, in prehospital and interfacility emergency care and transport of patients, of the medical knowledge, skills and techniques included in the departmentapproved training required for licensure of emergency medical technicians intermediate under ch. HFS 111 or emergency medical techniciansparamedic under ch. HFS 112 and which are not included in basic life support. "Interfacility transport" means scheduled or prearranged transportation of emergent or non-emergent patients between health care facilities. "Medical control" means direction, through verbal orders or a departmentapproved protocol, supervision and quality control by the medical director or by a physician designated by the medical director, of the activities of an EMT performing skills in the prehospital setting or during interfacility transport of a patient. "Operational Plan" means a document submitted for review and approval by DHFS that represents an ambulance service provider's plan for the delivery of emergency care and transportation of patients. "EMTALA" - The Emergency Medical Treatment and Active Labor Act enacted in 1986 and efavirenz. Recommendations pertaining to the benefits, risks, and utility of pharmacologic therapies are noted, including the strength of evidence.

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This section asks offerors to describe their capabilities in terms of developing, controlling, and managing an effective provider network. 1. Identify the type of network you propose. 2. Under the retail network you are proposing, are you willing to assume ownership i.e., responsibility for recruiting providers, exercising quality control, managing service and claim adjudication, and defending actions by allegedly wronged parties ; ? If not unconditional, describe your conditions for ownership in detail. Note: The Commonwealth's intent is not to own the network. ; 3. Define the scope and availability of your pharmacy network by completing a geo-access report with the below access standards. Include the summary pages following this question, include the entire report as an attachment please note the location of that attachment in your proposal here ; , and you must provide an electronic file containing the match results. Preferred formats for the electronic file are ASCII include the file format ; , Access or Excel and sustiva. Generic allergy relief drugs advair aerolate allegra benadryl bricanyl claritin d decadron dramamine periactin phenergan proventil serevent singulair ventolin zyrtec exelon sumycin diflucan sporanox elimite vermox eskalith haldol lamictal lithobid mellaril prolixin risperdal achromycin amoxyl bactrim biaxin ceclor ceftin ciloxan cipro duricef floxin garamycin keftab levaquin noroxin spectrobid trimox vibramycin zithromax anafranil celexa effexor xr elavil luvox pamelor paxil prozac sinequan tofranil wellbutrin zoloft buspar arava cataflam feldene imuran indocin sr mobic naprelan relafen zyloprim alesse ortho tri cyclen triphasil ditropan leukeran aceon adalat atacand avapro calan capoten cardizem cardura cilexetil combipres cordarone coreg coumadin cozaar diovan esidrix hydrodiuril hytrin hyzaar imdur ismo isoptin isordil lanoxin lasix lisinopril lopressor lotensin lozol minipress moduretic monoket norpace norvasc persantine plavix plendil pletal prinivil prinzide procardia rocaltrol sorbitrate tenoretic ticlid trental vaseretic vasodilan vasotec zebeta zestril lipitor lopid mevacor pravachol zocor actos amaryl avandia diamicron glucophage glucophage sr glucotrol glucotrol xl glucovance micronase prandin precose starlix aldactone microzide oretic dilantin neurontin aciphex bentyl colace cytotec detrol imodium nexium pepcid ac max strength prevacid prilosec protonix reglan zantac zofran propecia proscar combivir epivir retrovir viramune zerit cycrin danocrine deltasone levothroid prednisone provera synthroid altace inderal tenormin vastarel aralen flagyl grisactin myambutol cialis levitra viagra viagra gel viagra soft tabs antivert flexeril flextra ds robaxin soma zanaflex betagan evista fosamax mestinon sandimmune advil anacin celebrex esgic plus fioricet imitrex medipren panadol ponstel pyridium tylenol ultram eldepryl tegretol condylox rebetol zovirax atarax cleocin differin kenalog nizoral retin a synalar temovate ambien zyban compazine meridia aygestin clomid motrin naprosyn nolvadex parlodel serophene generic micronase, glibenclamide glyburide online price compare generic micronase glibenclamide glyburide ; buy online micronase, glibenclamide glyburide is an anti-diabetic medicine sulfonylurea-type ; which is used along with a proper diet and exercise program to control high blood sugar.

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Do not give this medication to anyone younger than 16 years old without the advice of a doctor. H., Stimulation with thromboxane A2 TXA2 ; receptor agonist enhances ICAM-1, VCAM-1 or ELAM-1 expression by human vascular endothelial cells, Clin. Exp. Immunol., 112, 464-70 1998 ; . 61 ; Lund T. and Osterud B., The promoting effect of epinephrine on lipopolysaccharide-induced interleukin-8 production in whole blood may be mediated by thromboxane A2, J. Thromb. Haemost., 1, 1042-1047 2003 ; . 62 ; Inoue Y., Tokuyama K., Nishimura H., Arakawa H., Kato M., Mochizuki H. and Morikawa A., Effects of STA2, a thromboxane A2 mimetic, in inducing airflow obstruction and airway microvascular leakage in guinea pigs, Pharmacology, 65, 62-68 2002 ; . 63 ; Squadrito F., Ioculano M., Altavilla D., Zingarelli B., Canale P., Campo G.M., Saitta A., Oriti S., Spignoli G. and Caputi A.P., G619, a dual thromboxane synthase inhibitor and thromboxane A2 receptor antagonist, reduces myocardial damage and polymorphonuclear leukocyte accumulation following coronary artery occlusion and reperfusion in rats, Pharmacology, 47, 167-175 1993 ; . 64 ; Keelan J.A., Sato T.A., Gupta D.K., Marvin K.W. and Mitchell M.D., Prostanoid stimulation of cytokine production in an amnion-derived cell line: evidence of a feed-forward mechanism with implications for term and preterm labor, J. Soc. Gynecol. Investig., 7, 37-44 2000 ; . 65 ; Shimabukuro D.W., Sawa T. and Gropper M.A., Injury and repair in lung and airways, Crit. Care Med., 31 Suppl ; , S524-S531 2003 ; . 66 ; 67 ; Abraham E., Neutrophils and acute lung injury, Crit. Care Med., 31 Suppl ; , S195-S199 2003 ; . Fan J., Ye R.D., and Malik A.B., Transcriptional mechanisms of acute lung injury, Am. J. Physiol. Lung Cell Mol. Physiol., 281, L1037-1050 2001 ; . 68 ; Kurdowska A, Noble J.M., Grant I.S., Robertson C.R., Haslett C. and Donnelly S.C., Anti-interleukin-8 autoantibodies in patients at risk for acute respiratory distress syndrome, Crit. Of Pharmacology, Abeno. Osaka 545. Osaka City, for instance, hypertension. Contraceptive development. Once it was the exciting new frontier, holding promise for a dramatic new product that would easily, safely and effectively prevent unwanted pregnancy. Pharmaceutical companies invested in research and, during the decades, brought forward new products. Today, due to market risks and perceived liability, pharmaceutical companies no longer invest so actively as before in the development of new contraceptive methods.1 Amidst achievements have been many disappointments, leaving many reproductive choice proponents today wondering "Where next?" Today one exciting success story is "emergency contraception." It is an important story that demonstrates the many pieces of the puzzle that need to fall into place in order to successfully bring a new product to market -- one that women worldwide should have had 25 years ago. What is Emergency Contraception? Emergency contraception is a method to prevent pregnancy after unprotected intercourse. The most common form consists of birth control pills taken after unprotected sex -- often called the "morning-after pill." Emergency contraceptive pills are effective if taken within 72 hours three days ; after unprotected sex. They prevent pregnancy by preventing ovulation, fertilization or implantation. 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This is my first Newsletter as Chair of our Committee. I want to thank all of our members for their support and participation in our Committee. I encourage each member to continue to be active in our Committee and challenge each member to attend at least one TIPS meeting this year. We want to continue to be a resource for our members. In the very capable hands of Leonard Nason, our Webmaster, we are updating our webpage to provide more content and information to our members. When completed the website should be a great resource for our membership. Mike Fish, our current Membership Coordinator, is exploring several methods to increase active participation in our Committee. Next year in Hawaii, Anthony Macaulay "Tony" ; , the current Chair-Elect will assume leadership of the Committee. This year, Tony has been included in every event and with Jill Mulder, Mike Fish, Leonard Nason and Karen Tashima has formed a kitchen cabinet to provide continued leadership for the Committee and to ensure that there is sufficient institutional knowledge among our leadership. Additionally, Tony is our point person on the TIPs Employment & Benefits Working Group. We hope to have several long distance seminars next year to provide opportunities for our members to keep abreast of changes in the law and to provide our membership with speaking and networking opportunities. This past year we worked with the Labor and Employment Section regarding an Informed Consent proposal. While the proposal was not adopted, it was another example of the cooperation that the ABA fosters among its members. The Informed Consent project and the Medicare Set Aside project, which has been around for several years, have allowed our Committee to have several members who are well-versed in this area. We have been approached and have been able to provide speakers to another Committee that was seeking speakers on Medicare Set Asides. In closing, I would like to thank Sharon Murphy, for compiling this Newsletter and for continually providing me with advice regarding our Committee. I look forward to working with you next year and wish you a happy new year. Mark Baugh Baker Donelson et al LLP. 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California Davis, Tulare, 2Balchem Corporation, Animal Nutrition & Health, New Hampton, NY. Objectives were to determine the effects of feeding RPC on lactation and metabolism in dairy cows. In Experiment 1 E1 ; , 369 cows were fed 15 g d RPC Reashure, Balchem ; from 25 d prepartum to 80 d milk DIM ; . In E2, 578 primigravid cows were fed 15 g d RPC in the 21 d prepartum. Blood was sampled from 80 cows in E1 and 47 cows in E2, and analyzed for concentrations of nonesteried fatty acids NEFA ; and glucose at 1, 14 and 21 DIM. Blood from all cows was analyzed for concentrations of 3-OH-butyrate BHBA ; at 1 and 14 DIM. Subclinical ketosis was considered when BHBA was greater than 1.0 mMol L. Hepatic tissue from 46 cows in E1 sampled at 8 DIM was analyzed for concentrations glycogen and triglycerides. Body condition was scored at enrollment, 1, 30, 60, and 90 DIM in E1, and at enrollment and calving in E2. Monthly yields of milk and milk components in E1 and weekly yields of milk in E2 were measured for 90 DIM. Prepartum DM intake was similar P 0.15 ; between treatments and averaged 12.5 and 10.5 kg d for E1 and E2, respectively, but intake tended P 0.10 ; to be greater for cows fed RPC 23.9 vs 22.6 kg d ; in E1. In E1, yields kg d ; of 3.5% FCM 44.6 vs 42.8 ; , ECM 40.1 vs 38.5 ; , and milk fat 1.61 vs 1.52 ; were greater P 0.05 ; , and of milk 43.1 vs 42.1 ; and true protein 1.21 vs 1.17 ; tended P 0.08 ; to be greater for RPC than control. Energy output in milk was greater P 0.03 ; for RPC than control 30.0 vs 28.8 Mcal d ; , although milk NEL content was similar and averaged 0.70 Mcal kg. In E2, milk yield tended P 0.07 ; to be greater for RPC than control 28.7 vs 27.9 kg d ; . Body condition was improved P 0.01 ; postpartum for RPC in E1. Concentration of glucose tended to be greater P 0.10 ; in E1 and of NEFA was smaller P 0.05 ; at calving in E2 for RPC compared with control. Prevalence of subclinical ketosis tended P 0.07 ; to be smaller at calving in all cows 28.5 vs 37.2% ; and was smaller P 0.05 ; in multiparous cows 22.1 vs 40.0% ; fed RPC in E1, but did not differ between treatments in E2. Feeding RPC improved lactation and metabolism of dairy cows, but benets were enhanced when it was fed prior to and after calving. Key Words: Choline, Dairy Cow, Subclinical Ketosis.

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The Official Publication of the CMSC, RIMS and IOMSN reflect particular vulnerability of color-carrying parvocellular fibers to injury.5 The sensitivities of the first 25 plates of the complete edition of ITCB and visual evoked potentials VEPs ; have been compared in 2 studies for patients with MS6, 7 and for patients with optic neuritis8 in a third study. All 3 studies reported a sensitivity for the VEP that was about twice that for ITCB in distinguishing patients with MS Table 1 ; . In the 2 studies of patients with MS, 6, 8 approximately 10% of the eyes with good visual acuity had an abnormality by ITCB not identified as abnormal with VEPs. This observation suggested that ITCB might be a useful adjunct to the clinical examination. In a small pilot series of 24 patients, we administered the first 11 plates of ITCB, 1995 concise edition Kanehara & Co, Ltd, Tokyo ; . This procedure required about 1 minute of technician time and was highly reproducible data not shown ; . Based upon the results of that study, we compared the ability of ITCB and VEPs to uncover visual disturbances in MS patients with subjectively normal vision. Table 1. Studies Comparing ITCB With VEP in Patients With MS and Optic Neuritis Abnormal ITCB and % % Abnormal Abnormal Normal VEP VEP ITCB 63% 82 130 ; eyes 32% 14 44 ; eyes 22% 13 58 ; patients 7 65 patients No data 5 59 normal eyes.
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